Wakarchuk Lab

The Wakarchuk Lab for GlycoScience

Glycobiology Lab

Group Photos

March 2018: (L to R starting at the front) Sadia (link to AntonescuLab here), Ting, Ray, Nakita, Bettina, Tasnim, Warren, Laura, Aj, Nathan, Hirak, You.

Crew

Warren W. Wakarchuk

Principal Investigator

Warren has been leading a glycobiology team since 1994. His expertise is in carbohydrate active enzymes, especially their structure and function. His team has been developing enzymes for the synthesis of bioactive molecules in vitro and in vivo. When not directing the team he can found cooking or playing guitar.

Nakita Buenbrazo MSc

Lab Manager

Nakita divides her time among all the projects in the Wakarchuk lab. She is an expert in enzymatic synthesis, master of protein expression and purification. Nakita has a passion for teaching and has trained many of the Wakarchuk lab undergrad alumni!

Aju-Sue Francis MSc

Technician

Aj has been applying her microbiology expertise to using Corynebacterium glutamicum as an expression host for a variety of proteins of interest to the Wakarchuk lab. She is helping to develop new expression vectors for this work.

Nicole Thompson BSc

Technician

Nicole is recent graduate of Waterloo University. She is working on enzymatic modification of glycopeptides, as well as characterizing the protein glycosylation performed by the synthetic OGO operons in E. coli.

Hirak Saxena MSc

PhD Candidate

Hirak has taken on a lead role in unravelling the O-mannosylation in Actinobacteria. He is applying synthetic biology to studying the biochemistry of this process in the hope of working out if this modification is coupled to protein export, and if there is a communication component to the story. He has also been working on the in vitro remodelling of therapeutic protein glycans.

Tasnim Abukar BSc

MSc Candidate

Tasnim is working between the Wakarchuk and Koivisto labs. Her chemical biology expertise is being applied to making fluorescent probes for enzyme studies as well as binding protein discovery and characterization.

Sadia Rahmani BSc

MSc Candidate

Sadia is working between the Wakarchuk and Antonescu labs (link to Antonescu lab here). Sadia’s cell biology expertise is being applied to functional studies of recombinant therapeutic proteins from the OGO project, as well studying how the O-GlcNAc modification is playing a role in regulation of clathrin mediated endocytosis.

Alumni

Laura Kell MSc (MSc 2016 to 2018)

Biprajit Sanyal BSc (MSc Candidate 2018)

Dr. Bettina Janesch (Postdoctoral Fellow 2016-2018)

Dr. Ting Du (Postdoctoral Fellow 2016-2018)

Alison Mark (COOP student 2017)

Vika Bardahl (COOP student 2016)

Tina Papazatos (COOP student 2016)

Dr. Lyann Sim (Postdoctoral Fellow 2013-2015)

Andrea Caple (COOP student 2015)

Brian Lam (COOP student 2015)

Mahrin Aziz (COOP student 2015)

Alejandra Culebro (Visiting PhD student, University of Helsinki, Dec 2014-Feb 2015)

Tamara Erak (MSc Candidate 2014-2015)

Bryan Hsu (4th year thesis student)

Soheilali Karmali (Volunteer/summer student, Sep 2013-Aug 2014)

Marc de Asis (2011-2013 MSc, Waterloo)

Katrina Delos Santos (Research assistant, Sep 2013-Aug 2014)

Gary Chan (Summer student 2013)

Liza Calhoun (COOP student 2013)